群馬大学大学院 医学系研究科生命医科学専攻 入学案内2018(英語版)
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10Graduate School of MedicineDescription of Research Objectives According to the change of life style and an increase in aged population, the prevalence of hypertension, diabetes, and metabolic syndrome is rapidly increasing. These changes lead to the increase in cardiovascular disease such as myocardial infarction, stroke and heart failure. This department has been interested in the pathogenesis of atherosclerosis and heart failure. In addition, this department aims to identify the molecular target to prevent or treat the fatal arrhythmia. Furthermore, we are interested in the molecular mechanism of pulmonary brosis. Since the completion of human genome sequence determination, life science enters into post-genome era that make possible development of tailor-made medicine, and advances in high-throughput genotyping herald a rapid expansion of genomic information in human disease. Recently, this department has been interested in the identication of biomarkers that have incremental value for prevention of cardiovascular and pulmonary disease, and key molecules that are targetable by drugs. With identication of putative risk alleles for heart failure or pulmonary brosis, the next step will be exploration of the function of the genes and prospective clinical trials evaluating the benets of genotype-directed treatment of cardiovascular and pulmonary disease.【Keywords】vascular biology, atherosclerosis, heart failure, myocardial infarction, transcription factors Cancer, and apoplexy and myocardial infarction due to arteriosclerosis, which account for two thirds of deaths in Japan, are caused by abnormalities of endocrine and metabolic systems, various gene mutations, and/or viral infection. We have investigated the pathogenesis of these disorders using animal models such as knockout mice, and examined gene abnormalities of samples obtained from the surgery to establish new methods of the diagnosis and therapy. 【Keywords】lifestyle-related diseases, endocrine-metabolic disorders, diabetes mellitus, respiratory allergy disorders, hepatometabolic-digestive disorders In Division of Gastroenterological Surgery, researches for whole digestive tract are included. A wide variety of research, which including mechanism of carcinogenesis, growth and invasion of tumor, metastasis of tumor, suppressive research of malignancy and gastrointestinal motility research with conscious dogs, it will read to new therapeutic treatment have been energetically performed. Moreover, several clinical researches including development of excellent diagnostic method and therapeutic method have been performed continuously for the future.【Keywords】gastrointestinal surgery, carcinogenesis, gastrointestinal motility, excellent diagnostic method, development of therapeutic method The Department of Radiation Oncology practices radiation therapy for various cancers comprehensively. It undertakes basic research on radiation induced apoptosis, modulation of radiation sensitivity by cell cycle regulatory proteins, hypoxia, cell- proliferation proteins, oncogenes, and cancer vasculature. In addition, clinical researches on heavy ion radiotherapy, combination of molecular targeted therapy with radiation, image based brachytherapy, and high precision radiotherapy (IMRT,SBRT, etc) are extensively conducted and promoted.【Keywords】radiation therapy, heavy ion therapy, radiation biology, radiation oncology, radiation pathology After the discovery of X-ray CT, there have been incredible advances in diagnostic imaging and it is now indispensible to modern medical care. In addition to CT, MRI, Ultrasound, PET, and SPECT, and the image-guided, minimally invasive techniques of interventional radiology and radioisotope therapy contribute to patient quality of life, and are also hoped to advance medical care. This eld researches and new techniques in combining morphological and functional imaging and developing “patient-friendly" treatment methods such as interventional radiology and radioisotope therapy.【Keywords】Diagnostic Radiology, Nuclear Medicine, CT, MRI, US, SPECT, PET, Interventional Radiology Development in neurosciences and brain sciences is just revealing brain dysfunctions for etiology and pathophysiology of psychiatric disorders using neuroimaging and genetic studies. Department of Psychiatry and Neuroscience endeavors to clarify etiology and pathophysiology of “mental dysfunction” employing structural neuroimaging such as MRI, functional neuroimaging such as PET and NIRS, neurophysiology such as MEG, neuroendocrine stress responses such as DST, and animal model of psychiatric disorders.【Keywords】psychiatric disorder, neuroimaging, stress, mental illness, brain function In our department, we are going to study about many problems in gerontology, especially methods of nutrition for old people. We are interested in the eects of the lack of trace elements on immune systems or protection to infectious disease.【Keywords】general medicine, gerontology, primary care, nutritionMasahiko KurabayashiCardiovascular MedicineMasanobu YamadaEndocrinology and MetabolismHiroyuki KuwanoGastroenterological SurgeryTakashi NakanoRadiation OncologyYoshito TsushimaDiagnostic Radiology and Nuclear MedicineClinical MedicineMasato FukudaPsychiatry and NeuroscienceJunichi TamuraGeneral Practice Medicine (Internal Medicine) (Internal Medicine) (General Surgical Medicine) (Due to retire in March 2018)GUNMA UNIVERSITYGraduate School of MedicineAdmission guidance 2018
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