群馬大学大学院 医学系研究科生命医科学専攻 入学案内2018（英語版）

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11Graduate School of Medicine　Rehabilitation medicine is a transverse eld of diagnostic as well as therapeutic medicine for infant-to-elder patients with a great variety of diseases. The course of rehabilitation medicine consists of basic knowledge of rehabilitation medicine, which are kineology, central and peripheral nerve system, respiratory, cardiac systems and psychiatry. The students discuss the methods for evaluation of disabilities and the equipment for the measurements. The indications of scales, rating scores and other evaluation methods for functional and mental disorders will be studied. Biological and cytological methods are also applied to the analysis, and the cellular reaction by physical stimulation will be observed. Statistical analysis will be indicated for the measurements and evaluations. Investigation of the results and publishing some conclusions in the journal is the purpose of the courses.【Keywords】disability medicine, diagnostic medicine, therapeutic medicine, kinesiology　Modern medicine and preventive medicine aim at the evidence based medicine (EBM). Clinical laboratory medicine plays a key role in EBM. Therefore the research eld of clinical laboratory medicine extends to every eld. We are investigating sports medicine and pathophysiology of diabetes, thyroid diseases, atherosclerosis and infectious diseases using gene analysis and new methods.【Keywords】gene analysis, diabetes mellitus, thyroid disease, atherosclerosis, infectious diseases, sports medicine, 　　　　　　clinical laboratory medicine, lifestyle-related disease　Pathology has dual aspects, one is basic science that aims to investigate causes of diseases, and the other is pathological diagnosis and classication of diseases. We shed light on neuropathology for years, and investigate pathogenesis, pathological diagnosis, and novel therapy of various diseases of the nervous system. Especially, our research group consistently plays a central role of brain tumor pathology of Japan for decades. We chiey handle human samples, and also possess original transgenic animals prone to brain tumors.【Keywords】neuropathology, brain tumor, molecular and cytogenetics of tumor, glial cells,translational research　Cancer is a “genetic disease” and oncogene and tumor suppressor genes have a great inuence to carcinogenesis. Most cancers develop by multi-step accumulation of genetic mutation with environmental and morphological changes. The main purpose of the course is to clarify the genetic change from morphological change or gene-related protein expression during cancer development and feedback to the diagnostic tumor pathology.【Keywords】cancer morphology, multi-step carcinogenesis, oncogene, tumor suppressor gene, protein expression　Chromatin is the most gigantic intra-cellular structure, which consists of genomic DNA with a length of more than 2 meters and associated proteins. Understanding of how this gigantic structure is organized and stored in the nucleus with a radius of ～10 micro meters while being ready to exert a wide variety of its coordinated functions is a central question. Our aim is to reveal regulatory mechanisms of gene expression in dierentiating neural cells and post-mitotic neurons to understand brain development and its functions. We specically focus on sub-nuclear spatial organization and post-translational modications of chromatin, and their relevance in gene regulation in the nervous system.【Keywords】Chromatin, nuclear organization, epigenetics, transcription, neural cells　The understanding of hormonal eects and interactions on the hypothalamo-pituitary-ovarian axis is important for comprehending reproductive physiology and pathophysiology. The hormones work on the axis in a well-coordinated way and maintain physiological homeostasis. The aim of our research is to understand the functions of hormones at the molecular level, leading to the discovery of biologically active substances such as hormones and growth factors and their functional mechanisms. Our research involves the interrelationship between structures and functions of hormone receptors to elucidate the functions and mechanisms of actions of gonadotropin receptors.【Keywords】LH receptor, FSH receptor, mutation, intracellular signal transduction, epigenetics　Our department has focused on understanding of the pathophysiology of prostate cancer. Basic studies cover genetic analysis, the role of lipids and intratumoral hormonal environments. Clinical studies cover the role of the tumor marker PSA and screening of prostate cancer.【Keywords】Urological tumor, prostate cancer, androgen dependency, screeningNaoki WadaRehabilitation MedicineMasami MurakamiClinical Laboratory MedicineHideaki YokooHuman PathologyTetsunari OyamaDiagnostic PathologyHirokazu ArakawaPediatrics (Under Selection)Obstetrics and GynecologyKazuhiro SuzukiUrology