群馬大学大学院 医学系研究科生命医科学専攻 入学案内2018（英語版）

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12Graduate School of Medicine　Antitumor immunity plays an important role in protection against the development of malignancy. However, with a developing tumor, tumor cells acquire various mechanisms to corrupt the host antitumor responses, escape from immunosurveillance system, and grow in the host. The followings are current studies being conducted. 1) Immunological analysis of T cells in patients with head and neck cancer 2) Analysis of interaction between tumor cells and stromal cells in head and neck cancer.【Keywords】head and neck cancer, immunosuppression, cancer vaccine, tumor microenvironment　Recently, many new drugs with novel mechanisms have produced to improve the clinical ecacy of drug therapy, however, the development of new drugs also have produced a lot of new problems to be solved. In the pharmacotherapy, the choice of appropriate therapy or drugs for each individual patient is imperative. To establish safe and eective pharmacotherapy, we focus the variation factors for clinical ecacy of drug therapy for several diseases with gene analysis and pharmacokinetic approaches.【Keywords】Clinical pharmacology, pharmacokinetics, genetic polymorphisms, individualization of drug therapy　This department was newly founded in April of 2017 to study and promote quality and safety in healthcare, cooperating with international organizations such as WHO, etc. We are now selecting a candidate for the professor of this department.　Clinical trials and research are advanced very rapidly and changed dramatically in recent years. We conduct and support a variety of clinical trials in our hospital and in our community to establish highly qualied clinical evidence. We continuously improve our knowledge and skills about trial design, data management, statistical methods, regulatory science or ethical issues in daily practice. We are trying to open a door for new world of clinical research science.【Keywords】clinical research, study design, statistics　Today’s rapid growth of hospital information systems produces huge amount of data and excellent infrastructure to let clinicians to access them. This seminar aims to learn methodology contributing human health care using medical information system. It has been exploring and presenting required data via hospital information system using ubiquitous computing technologies.【Keywords】medical information, health care, hospital information system　Membrane tracking plays essential roles not only in secretion and nutrient uptake but also in various physiological processes such as the endocrine system, the metabolic system, the nervous system, and animal development. In our laboratory, we study the molecular mechanisms and physiological functions of membrane tracking in multicellular organisms by using the nematode Caenorhabditis elegans and mice as model systems.【Keywords】membrane tracking, secretion, metabolism, development, C. elegans, knockout mouse　The deterioration of the synapses has attracted attention as the pathophysiology of neuropsychiatric disorders. Thus, we examine the relationship between the structural and functional property of synapse and behavioral manifestations by utilizing in vivo 2-photon imaging. Furthermore, we also utilize novel optogenetic tools, which can manipulate the plasticity of the synapse in order to alter neurocircuits by extension changing the behaviors. By these two strategies, we pursue the cellular mechanism of neuropsychiatric disorders to identify a novel therapeutic target for disorders.【Keywords】europsychiatric disorders, synapse, 2-photon imaging, signal transduction, drug discoveryKazuaki ChikamatsuOtolaryngology Head and Neck SurgeryKoujirou YamamotoClinical PharmacologyQuality and Safety in Healthcare (tentative)Yuichiro Saito (Associate Professor)Medical InformaticsKen SatoMolecular TracAkiko Hayashi-TakagiMedical NeuroscienceCooperative and Joint Department（University Hospital）Description of Research ObjectivesClinical Trials and Regulatory ScienceTetsuya Nakamura（Institute for Molecular and Cellular Regulation）GUNMA UNIVERSITYGraduate School of MedicineAdmission guidance 2018