群馬大学大学院 医学系研究科生命医科学専攻 入学案内2018（英語版）

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14Graduate School of Medicine　Morphogen signaling systems, such as Wnt signaling, plays crucial roles in animal tissue morphogenesis and homeostasis, and dysregulation of morphogen signaling causes a variety of diseases, including cancer, metabolic diseases, and neurological diseases. Our laboratory investigates the regulatory mechanisms of morphogen signaling systems and also searches for unknown signaling systems that regulate tissue morphogenesis and homeostasis, using in vivo imaging, biochemistry, and molecular genetics. Especially, we are now focusing on "cell competition", a new system supporting animal tissue homeostasis.【Keywords】signal transduction, morphogen, cell competition, in vivo imaging, disease model　In this course, we aim to nurture researchers in the eld of medical physics who are indispensable for ensuring the reliability of radio therapy through sophisticated research and credible study of heavy ion and x-ray radiotherapies. To improve radiotherapy and to use space environment we carry out in vitro and in vivo experiments regarding a variety of radiation-induced biological phenomena. Another important purpose of this course is to increase the expertise of those radiobiology specialists involved in radiotherapy and space science.【Keywords】Radiotherapy, heavy ion radiotherapy, medical physics, accelerator, radiation biology, eect of space radiationTohru IshitaniLaboratory of Integrated Signaling SystemsLocation（Showa Campus）Graduate School of MedicineFaculty of Medicine University Hospital3-39-22,Showa-machi,Maebashi,Gunma 371-8511Telephone+81-27-220-71113-39-15,Showa-machi,Maebashi,Gunma 371-8511Description of Research ObjectivesMasami Torikoshi　Akihisa TakahashiMedical Physics and Biology for Ion Therapy(Heavy Ion Clinical Medicine)　Heavy ion radiotherapy for malignant tumors has several biophysical advantages compared with photon therapy. Heavy ion clinical medicine includes radiobiology, medical physics and engineering, tumor pathology, clinical oncology, and radiation diagnosis. This course is implemented to understand that the radiation oncology including heavy ion radiotherapy is comprehensive medical science which integrates and systematizes these wide varieties of scientic subelds to attain successful cancer treatment.【Keywords】heavy ion radiotherapy, multimodality cancer therapy, biological response, high LET, hypofractionation, 　　　　　　Image-guided adaptive radiotherapy　We are researching biological functions at the molecular, cellular and tissue levels using the physical and biological eects of ion beams at the ion beam irradiation facility of Takasaki Advanced Radiation Research Institute. Our nal goal is the development of new methods of analyzing biological function not possible with previously established methods. The major subjects are as follows:・Making advances in micro-PIXE (Particle Induced X-ray Emission) analysis,・Developing a technology to target and hit a cell or a tissue with a single-heavy-ion of several hundred MeV within 1μm spatial accuracy under microscope observation, Elucidating eects induced to normal or cancer human cells irradiated with heavy ions, and to those not irradiated (bystander eect).【Keywords】ion beam, microbeam, micro-PIXE, single-ion hit, irradiation of targeted cell, radiomicrosurgery, bystander eectTatsuya OhnoHeavy Ion Clinical MedicineYasuyuki Ishii　Yasuhiko KobayashiQuantum Biology(Takasaki Advanced Radiation Research Institute, National Institute for Quantum and Radiological Sciences and Technology)GUNMA UNIVERSITYGraduate School of MedicineAdmission guidance 2018