群馬大学大学院 医学系研究科生命医科学専攻 入学案内2019（英語版）

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11Graduate School of Medicine　To develop early diagnostic tools and establish useful biomarkers for Alzheimer disease, we are invesgating the Aβ-amyloid imaging (PIB-PET) and CSF biomarkers. To unravel a pathogenesis of the biggest intractable neurological disease, amyotrophic lateral sclerosis (ALS), we are investigating the autopsy tissues of ALS subjects. Microsatellite-repeat expansions of CAG, CTG, or GGCCTG repeat units are common genetic mutations of the hereditary neurological disorders such as spinocerebellar ataxia (SCA). We are trying to establish cell culture or animal models which are aected by these mutations. We hope to develop a novel disease-modifying therapy for SCA by analyzing these models.【Keywords】Alzheimer disease, dementia, amyotrophic lateral sclerosis (ALS), spinocerebellar ataxia (SCA), microsatellite-repeat　According to an increase in aged population, the prevalence of arteriosclerotic diseases and heart failure are rapidly increasing, and part of such patients need surgical treatment. In cardiovascular surgery, organ ischemia occurs in almost all patients, and then the reduction of the ischemia-reperfusion injury is important to the surgical results. It is still controversial in the methods of myocardial protection and brain protection, and we study more eective methods for organ protection.【Keywords】surgery, heart, brain, ischemia, reperfusion injury, organ protection　The understanding of fundamental knowledge and concept of malignant diseases in thoracic surgical oncology, in particular, lung cancer, metastatic lung tumor, and thymic epithelial tumor is most important. The various factors related in each stage of carcinogenesis, proliferation, local invasion and also metastasis of tumor are reviewed with the latest knowledge. Furthermore, we make the students understand the importance of the recent advances in the diagnosis and treatment to patients with thoracic malignant disease. After clarifying the clinical problems, the students will learn the basic experimental techniques necessary for development of new diagnostic method and therapy in surgical science of future.【Keywords】surgical oncology, mechanism of proliferation, invasion and metastasis, driver gene, diagnosis and treatment　In Division of Gastroenterological Surgery, researches for whole digestive tract are included. A wide variety of research such as mechanism of carcinogenesis, growth and invasion of tumor, metastasis of tumor, suppressive research of malignancy and gastrointestinal motility research with conscious dogs have been energetically performed and will lead to new therapeutic treatment. Moreover, several clinical researches including development of excellent diagnostic method and therapeutic method have been performed continuously for the future.【Keywords】gastrointestinal surgery, carcinogenesis, gastrointestinal motility, excellent diagnostic method, development of　　　　　　therapeutic method　Breast cancer is the highest incidence disease among female malignant neoplasm. We review diagnosis and treatment of breast cancer and endocrine disorders. Basic research includes 1) mechanism of therapy resistance in breast cancer, 2) tumor angiogenesis, 3) biomarker of sensitivity for breast cancer treatment, 4) an exhaustive analysis of breast cancer prognostic factors. In addition, clinical study includes 1) additional usefulness of FDG-PET in breast cancer, 2) Mechanism of lymph node metastasis, 3) analysis of navigation surgery for identication of parathyroid glands and sentinel lymph nodes. It is not necessary to focus on the specic research subject, which you belong to. We held a research conference every week and discuss everything to solve the research problems with our professor.【Keywords】breast cancer, biomarkers, lymph node metastasis, TILs, microRNA, PET　In Department of Hepatobiliary and Pancreatic Surgery, main theme in basic research eld, for overcoming refractory cancer, such as hepatobiliary and pancreatic cancer is microenvironment of cancer. In the clinical research eld, important theme is new evaluation for liver function, sarcopenia, and laparoscopic surgery in hepatobiliary and pancreatic surgery in safe manner. For developing research, we will send young surgeons to outstanding research center.【Keywords】cancer microenvironment, hepato-biliary and pancreatic cancer, liver transplantation, sarcopenia, and laparoscopic　　　　　　surgery for hepato-biliary and pancreatic disease　We cooperate with other divisions of surgery and organize multidisciplinary research. Our main research subjects are development of new diagnostic and treatment methods with minimally invasive approach. In particular, we study the minimally invasive diagnosis using circulating tumor cells for childhood cancer, the development of new instruments in minimally invasive surgery, and the relation between gastro-intestinal motility and enterobacterial ora after total colectomy for ulcerative colitis.【Keywords】surgical oncology, circulating tumor cells, minimally invasive surgery, gastro-intestinal motility, enterobacterial oraYoshio IkedaNeurology (Internal Medicine)Tomonobu AbeCardiovascular Surgery (General Surgical Medicine)Akira MogiGeneral Thoracic Surgery (General Surgical Medicine)(Under Selection)Gastroenterological Surgery (General Surgical Medicine)Takaaki FujiiBreast and Endocrine Surgery (General Surgical Medicine)Ken ShirabeHepatobiliary and Pancreatic Surgery (General Surgical Medicine)Makoto SuzukiPediatric Surgery (General Surgical Medicine)