群馬大学大学院 医学系研究科生命医科学専攻 入学案内2019（英語版）

14/18

13Graduate School of Medicine　Modern medicine and preventive medicine aim at the evidence based medicine (EBM). Clinical laboratory medicine plays a key role in EBM. Therefore the research eld of clinical laboratory medicine extends to every eld. We are investigating sports medicine and pathophysiology of diabetes, thyroid diseases, atherosclerosis and infectious diseases using gene analysis and new methods.【Keywords】gene analysis, diabetes mellitus, thyroid disease, atherosclerosis, infectious diseases, sports medicine, 　　　　　　clinical laboratory medicine, lifestyle-related disease　Pathology has dual aspects, one is basic science that aims to investigate causes of diseases, and the other is pathological diagnosis and classication of diseases. We shed light on neuropathology for years, and investigate pathogenesis, pathological diagnosis, and novel therapy of various diseases of the nervous system. Especially, our research group consistently plays a central role of brain tumor pathology of Japan for decades. We chiey handle human samples, and also possess original transgenic animals prone to brain tumors.【Keywords】neuropathology, brain tumor, molecular and cytogenetics of tumor, glial cells, translational research　Cancer is a “genetic disease” and oncogene and tumor suppressor genes have a great inuence on carcinogenesis. Most cancers develop by multi-step accumulation of genetic mutation with environmental and morphological changes. The main purpose of the course is to clarify the genetic change from morphological change or gene-related protein expression during cancer development and feedback to the diagnostic tumor pathology.【Keywords】cancer morphology, multi-step carcinogenesis, oncogene, tumor suppressor gene, protein expression　Chromatin is the most gigantic intra-cellular structure, which consists of genomic DNA with a length of more than 2 meters and associated proteins. Understanding of how this gigantic structure is organized and stored in the nucleus with a radius of ～10 micro meters while being ready to exert a wide variety of its coordinated functions is a central question. Our aim is to reveal regulatory mechanisms of gene expression in dierentiating neural cells and post-mitotic neurons to understand brain development and its functions. We specically focus on sub-nuclear spatial organization and post-translational modications of chromatin, and their relevance in gene regulation in the nervous system.【Keywords】chromatin, nuclear organization, epigenetics, transcription, neural cells　Our research eld includes reproductive medicine & biology, gynecology and obstetrics. Main research interests are hypothalamus-pituitary-ovarian axis and endometriosis in the eld of reproductive medicine & biology, uterine and ovarian cancer in gynecology, and obstetrics complications. We adopt up-to-date techniques of molecular biology and epidemiology.【Keywords】reproductive endocrinology and biology, endometriosis, gynecologic malignancies and obstetrics complication　Our department has focused on understanding of the pathophysiology of prostate cancer. Basic studies cover genetic analysis, the role of lipids and intratumoral hormonal environments. Clinical studies cover the role of the tumor marker PSA and screening of prostate cancer.【Keywords】urological tumor, prostate cancer, androgen dependency, screening　Neurosurgical science had been evolved remarkably for recent 10 years with the introduction of new devices, including an endovascular catheter, an endoscope, and intraoperative monitoring systems, etc. These technical innovations make it possible to approach neurosurgical diseases with minimally invasive way. We will understand more deeply central nervous system, anatomically, pathologically, and biochemically, and develop pre-and-intraoperative neurophysiological, and imaging studies. Then, we pursue the truly sophisticated treatment for neurosurgical diseases.【Keywords】micro-neurosurgery, interventional radiology, endoscopic neurosurgery, intraoperative imaging, intraoperative　　　　　　neurophysiology　We are investigating 1) the mechanisms of pathogenesis in fundus diseases with optical coherence tomography (OCT) and 2) the lifetime of phosphorescence from iridium complex to develop a new system which can measure oxygen partial pressure in retinal tissue. Furthermore, our concern is also 3) the molecular mechanisms of damages in photoreceptor after retinal detachment using animal models.【Keywords】optical coherence tomography, iridium complex, phosphorescence, oxygen partial pressure, retinal detachmentMasami MurakamiClinical Laboratory MedicineHideaki YokooHuman PathologyTetsunari OyamaDiagnostic PathologyPediatricsAkira IwaseObstetrics and GynecologyKazuhiro SuzukiUrologyYuhei YoshimotoNeurosurgeryHideo AkiyamaOphthalmology