群馬大学大学院 医学系研究科生命医科学専攻 入学案内2019（英語版）

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14Graduate School of Medicine　Antitumor immunity plays an important role in protection against the development of malignancy. However, with a developing tumor, tumor cells acquire various mechanisms to corrupt the host antitumor responses, escape from immunosurveillance system, and grow in the host. The followings are current studies being conducted. 1) Immunological analysis of T cells in patients with head and neck cancer 2) Analysis of interaction between tumor cells and stromal cells in head and neck cancer.【Keywords】head and neck cancer, immunosuppression, cancer vaccine, tumor microenvironment　Our research goal is “Bedside to Bench and Bench to Bedside” to cure and care patients suering from diseases of unknown etiology or intractable diseases. Our experienced sta supervises and assists you to publish the high quality paper to the world. Our main research themes are as follows: systemic sclerosis, dermatomyositis, viral infection, wound healing, cutaneous malignant neoplasms, and hereditary disease.【Keywords】skin, autoimmune rheumatic disease, cutaneous malignant neoplasms, wound healing, hereditary diseases　We are investigating in collaboration with department of Oral and Maxillofacial Surgery and Dermatology. Present research theme are1) Clinical and experimental study wound healing.2) Clinical and experimental study of free ap reconstruction.3) Evaluation of breast, head and neck reconstruction with brainscience using MRI images.【Keywords】reconstruction, free ap, wound healing, breast reconstruction　Nowadays, it is important to facilitate the maintenance and improvement of bone and joint function. The aim of our department contributes further to the development of musculoskeletal medicine through research, maintenance of health, prevention of diseases, development of public health in both mind and body mainly through sports medicine, support for the handicapped, and extension of social welfare services for the aged.【Keywords】osteoarthritis, spondylotic deformans, joint arthroplasty, sports injury, musuclo-skeletal tumor　Recently, many new drugs with novel mechanisms have produced to improve the clinical ecacy of drug therapy, however, the development of new drugs also have produced a lot of new problems to be solved. In the pharmacotherapy, the choice of appropriate therapy or drugs for each individual patient is imperative. To establish safe and eective pharmacotherapy, we focus on the variation factors for clinical ecacy of drug therapy for several diseases with gene analysis and pharmacokinetic approaches.【Keywords】clinical pharmacology, pharmacokinetics, genetic polymorphisms, individualization of drug therapy　Present research theme1) Epithelialization in oral mucous wound healing in terms of energy metabolism.2) Cytological evaluation in odontogenic cyst-lining keratinocyte.3) Oral and maxillofacial reconstruction with vascularised free aps.4) Evaluation of treatment strategy of oral cancer.5) Eects of pilocarpine and isoproterenol on aquaporin-5 expression in salivary gland6) Clinical and experimental study of endodontic microsurgery for extensive radicular cyst.7) Surgical study of jaw deformity【Keywords】oral mucous wound healing, oral and maxillofacial reconstruction, oral cancer, salivary gland, jaw deformity　Discipline of healthcare quality and safety aims to promote evidence-based, patient-centered quality healthcare through education, practice, and research utilizing multidisciplinary approach. Areas of interests include application of quality and safety indicators, studies of decision making process including shared decision making, development of methodology for analysis and prevention of medical errors, and promotion of interprofessional collaboration.【Keywords】healthcare quality, patient safety, quality indicator, shared decision making, interprofessional collaborationKazuaki ChikamatsuOtolaryngology Head and Neck SurgeryOsamu IshikawaDermatologySatoshi YokooPlastic SurgeryHirotaka ChikudaOrthopaedic SurgeryDescription of Research ObjectivesKoujirou YamamotoClinical Pharmacology and TherapeuticsSatoshi YokooOral and Maxillofacial SurgeryQuality and Safety in HealthcareYasuhiro Komatsu　Clinical trials and research are advanced very rapidly and changed dramatically in recent years. We conduct and support a variety of clinical trials in our hospital and in our community to establish highly qualied clinical evidence. We continuously improve our knowledge and skills about trial design, data management, statistical methods, regulatory science or ethical issues in daily practice. We are trying to open a door for new world of clinical research science.【Keywords】clinical research, study design, statisticsCooperative Department（University Hospital）Clinical Trials and Regulatory ScienceTetsuya NakamuraGUNMA UNIVERSITYGraduate School of MedicineAdmission Guide 2019