群馬大学大学院 医学系研究科生命医科学専攻 入学案内2019（英語版）

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15Graduate School of Medicine　Today’s rapid growth of hospital information systems produces huge amount of data and excellent infrastructure to let clinicians to access them. This seminar aims to learn methodology contributing human health care using medical information system. It has been exploring and presenting required data via hospital information system using ubiquitous computing technologies.【Keywords】medical information, health care, hospital information system　Membrane tracking plays essential roles not only in secretion and nutrient uptake but also in various physiological processes such as the endocrine system, the metabolic system, the nervous system, and animal development. In our laboratory, we study the molecular mechanisms and physiological functions of membrane tracking in multicellular organisms by using the nematode Caenorhabditis elegans and mice as model systems.【Keywords】membrane tracking, secretion, metabolism, development, C. elegans, knockout mouse　The deterioration of the synapses has attracted attention as the pathophysiology of neuropsychiatric disorders. Thus, we examine the relationship between the structural and functional property of synapse and behavioral manifestations by utilizing in vivo 2-photon imaging. Furthermore, we also utilize novel optogenetic tools, which can manipulate the plasticity of the synapse in order to alter neurocircuits by extension changing the behaviors. By these two strategies, we pursue the cellular mechanism of neuropsychiatric disorders to identify a novel therapeutic target for disorders.【Keywords】europsychiatric disorders, synapse, 2-photon imaging, signal transduction, drug discovery　With the decrease of neuroendocrine function, a variety of diseases increase, which include metabolic syndrome and neuronal disorders. To understand fundamental mechanisms on such human diseases, we investigate the biosynthesis and secretion of peptide hormones, and the regulation of cell survival and death, with use of molecular and cellular technical approaches. In a collaborative study with some engineering researchers, we are also developing uorescent or luminescent probes for analyzing cancer, diabetes, and ischemia.【Keywords】peptide hormones, insulin, uorescent probes, molecular imaging, tumor cells ,cell death　Eukaryotic cells are composed of several membrane-bound organelles. The shape and composition of organells are dynamically regulated during cell dierentiation and are also inuenced by various changes in the extracellular environment. We are interested in the regulation of organelle dynamics during animal development and use C. elegans as a model system. In particular, we explore the mechanisms and physiological roles of autophagy and endocytosis in fertilized eggs by using genetic and cell biological approaches.【Keywords】C. elegans, embryonic development, organelle, autophagy, endocytosis　To understand the physiopathology of multicellular organisms, it is important to know how dierentiated cells communicate with each other to regulate their function as a whole body. We especially focus on the basic biology of pancreatic beta cells, adipocytes, and immune cells, because of their involvement in the pathogenesis of endocrine, metabolic, and allergic diseases such as diabetes, obesity, and asthma. We approach these themes at multiple levels from molecules to whole body, and by using varying techniques of molecular biology, biochemistry, cell biology, and genetics.【Keywords】genetically modied mouse, regulated exocytosis, endocrine, metabolic, and allergic disease, live cell imaging, cell sorting　The dysfunction of pancreatic cells or brown adipocytes can cause diabetes and metabolic syndrome. We aim to elucidate the mechanism involved in the maintenance of homeostasis in these higher-order function cells, which is the key to glucose metabolism, from a variety of viewpoints, including developmental biology, molecular biology, and physiology. Recent studies have indicated that zinc not only plays a crucial role in the maintenance of protein structure, but is also involved in intracellular and extracellular signal transduction. Our second aim is to clarify the role of zinc signaling in diabetes and obesity. Furthermore, using our ndings from basic medical research, we aim to establish a groundbreaking treatment for diabetes and obesity.【Keywords】 pancreatic β cell, development, autophagy, brown adipocyte, zinc biology, glucose metabolism　In this laboratory, we are trying to elucidate the molecular mechanism by which metabolic syndrome occurs, using genetically manipulated animal models, such as knockout mice or transgenic mice. We hope that our research will contribute to the development of new strategies to treat or prevent diabetes and obesity.【Keywords】diabetes, obesity, metabolic syndrome, transcription factor, knockout mouse, insulin, glucagonYuichiro Saito (Associate Professor)Medical InformaticsKen SatoMolecular TracAkiko Hayashi-TakagiMedical Neuroscience（Institute for Molecular and Cellular Regulation）Miyuki Sato (Associate Professor)Molecular Membrane BiologyTetsuro IzumiMolecular Endocrinology and MetabolismDevelopmental Biology and MetabolismYoshio FujitaniSeiji Torii (Associate Professor)Secretion BiologyTadahiro KitamuraMetabolic Signaling