群馬大学大学院 医学系研究科生命医科学専攻 入学案内2019（英語版）

9/18

8Graduate School of MedicineDescription of Research Objectives　Research themes of our laboratory are 1) molecular cell biology of functional proteins of the skeletal muscle and 2) expression and function of cell adhesion molecules during early development. For the former, we are now concentrating on studying cytoskeletal anchoring systems to the sarcolemma and vesicular sorting systems. For the latter, we are studying cadherin-superfamily proteins with in situ hybridization technique using zebrash embryos that are characterized by transparency in early development.【Keywords】skeletal muscle, cytoskeleton, vesicular sorting system, embryogenesis, cell adhesion proteins　We are interested in membrane channel proteins and transporter proteins, especially in water channel aquaporins. Our goal is to understand their physiological functions and relationships between these proteins and diseases. To understand the physiological functions of these proteins, we investigate their tissue distributions and cellular localizations as well as their changes by using bio-imaging techniques such as immunouorescence microscopy and immunoelectron microscopy, as well as techniques in molecular biology.【Keywords】membrane protein, water channel, transporter, immunouorescence microscopy, immunoelectron microscopy,　　　　　　molecular biology　We are studying the cells in the CNS from their birth to death. We aim to elucidate the molecular basis of the control of proliferation, dierentiation, and survival of neural precursor cells, hoping that our results will contribute to the treatment of intractable CNS diseases in the near future. We are also studying the interaction between neural cells and vascular cells in the CNS.【Keywords】neural stem cells, neuronal precursor cells, glial precursor cells, glial cells, vascular cells, regenerative medicine Our research projects aim to clarify turnover of cell membrane hospholipids on various kinds of stimulation, production of bioactive lipids (lipid mediators), signal transduction through their GPCRs, and function of these bioactive lipids, using methods of biochemistry, molecular biology and cell biology. Lipid mediators may be involved in various pathological processes such as inammation, allergic reaction, neurological disorders, and cancer proliferation. We are also working on analysis of signal transduction through DNA double strand break, and exhaustive analysis of protein and metabolite by mass spectrometry.【Keywords】lipid mediator, GPCR, signal transduction, DNA double strand break, proteome, metabolome　Small lipophilic hormones such as steroid and thyroid hormones play a crucial role in the development and functional maintenance of various organs including the central nervous system. On the other hand, there are drugs and environmental chemicals whose structures are similar to those of such hormones. Such chemicals may disrupt endogenous hormone actions as either an agonist or antagonist. We study the eect of small lipophilic hormones on organ development and plasticity, and modulation by environmental chemicals and drugs on such process, using various techniques including behavioral analysis with gene modied animals, and cellular and molecular biological techniques.【Keywords】hormone, development, plasticity, regeneration, environmental factors, endocrine disruption　We are studying the mechanism underlying memory, learning and motor control as well as brain disorders and aging in terms of molecular, cellular, network and behavioral aspects. Our challenge includes development of novel therapies eective for the brain disorders. To pursue these aims, we are developing cutting-edge techniques such as novel viral vectors, genome editing technology and disease model non-human primates. Our laboratory has sucient experimental setup to perform world top-level research.【Keywords】memory; learning; motor control; regenerative medicine; viral vector; neurodegenerative disease; marmoset;　　　　　　non-human primate model; aging; stem cell therapy; gene therapy; patch clamp.　To understand the regulatory mechanisms of synapse morphology and function, we have studied the actin cytoskeleton in postsynaptic sites. For this research, primary cultured neurons, human iPS cells-derived neurons and knockout mice have been used with various experimental techniques including cell biology, biochemistry, molecular biology, neuronal cell culture, histochemistry, imaging and behavioral analysis. In addition, we have also studied about the eects of radiation on the synapses. These studies will shed light on the mechanisms of brain function and development of new diagnostic and therapeutic methods for neurological and psychiatric disorders.【Keywords】synaptic morphology and function, actin cytoskeleton, imaging techniques, human iPS cells-derived neurons,　　　　　　radiation damage, high-throughputBasic MedicineAnatomy(Under Selection)Anatomy and Cell BiologyToshiyuki MatsuzakiMolecular and Cellular NeurobiologyYasuki IshizakiBiochemistry(Under Selection)Integrative PhysiologyNoriyuki KoibuchiNeurophysiology and Neural RepairHirokazu HiraiNeurobiology and BehaviorTomoaki ShiraoGUNMA UNIVERSITYGraduate School of MedicineAdmission Guide 2019