群馬大学大学院医学系研究科 医科学専攻(博士課程) 平成30年度入学案内(英語版)

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Contact Information and Main contents (contact number: +81-27-220-the extension number)RegionMajor FieldContact InformationMain contents of research and key wordsBasic MedicineAnatomyHiroshi Yorifuji※Ext. 7910yorifuji@gunma-u.ac.jpResearch themes of our laboratory are 1) molecular cell biology of functional proteins of the skeletal muscle and 2) expression and function of cell adhesion molecules during early development. For the former, we are now concentrating on studying cytoskeletal anchoring systems to the sarcolemma and vesicular sorting systems. For the latter, we are studying cadherin-superfamily proteins with in situ hybridization technique using zebra sh embryos that are characterized by transparency in early development.【Keywords】skeletal muscle, cytoskeleton, vesicular sorting system, embryogenesis, cell adhesionAnatomy and Cell BiologyToshiyuki MatsuzakiExt. 7900matoshi@gunma-u.ac.jp We are studying the function of cellular molecules and their relations to cell function and structure. We especially focus on membrane channels and transporters in the kidney, such as water channel aquaporins. We are studying the regulation of water channels and relations to polycystic kidney. To understand these molecules, we use bio-imaging techniques such as immunofluorescence microscopy and immunoelectron microscopy, as well as molecular biology techniques. We are also working on functional molecules in meiosis and cellular polarity. 【Keywords】cell membrane, water channels, transporters, microscopy, immunohistochemistry, electron microscopyMolecular and Cellular NeurobiologyYasuki IshizakiExt. 7950yasukiishizaki@gunma-u.ac.jpWe are studying the cells in the CNS from their birth to death. We aim at elucidation of molecular basis for the control of proliferation, di erentiation, and survival of neural precursor cells, hoping that our results will contribute to the treatment of intractable CNS diseases in the near future. We are also studying the interaction between neural cells (especially oligodendrocyte precursor cells) and vascular cells (especially endothelial cells). 【Keywords】neural stem cells, neuronal precursor cells, oligodendrocyte precursor cells, glial cells, endothelial cells, regenerative medicineBiochemistryTakashi Izumi※Ext. 7940 takashi_izumi@gunma-u.ac.jpOur research projects aim to clarify turnover of cell membrane phospholipids on various kinds of stimulation, production of bioactive lipids (lipid mediators), signal transduction through their receptors, function of these bioactive lipids, and signal transduction after DNA damage, using methods of biochemistry, molecular biology and cell biology. Lipid mediators are involved in various pathological processes such as in ammation, allergy, cancer, neurological disorders. We are also working on omics analysis of protein and metabolite by mass spectrometry.【Keywords】Lipid mediator, Receptor, Signal transduction, DNA damage, Omics analysisIntegrative PhysiologyNoriyuki KoibuchiExt. 7920 nkoibuch@gunma-u.ac.jpSmall lipophilic hormones such as steroid and thyroid hormones play a crucial role in the development and functional maintenance of various organs including the central nervous system. On the other hand, there are drugs and environmental chemicals whose structures are similar to those of these hormones. Such chemicals may disrupt endogenous hormone actions as either an agonist or antagonist. We study the e ect of small lipophilic hormones on organ development and plasticity, and modulation by environmental chemicals and drugs on such process, using various techniques including behavioral analysis with gene modi ed animals, and cellular and molecular biological techniques.【Keywords】hormone, development, plasticity, regeneration, environmental factors, endocrine disruption※Due to retire in March 2018 －127－