群馬大学大学院医学系研究科 医科学専攻(博士課程) 平成30年度入学案内(英語版)

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RegionMajor FieldContact InformationMain contents of research and key wordsBasic MedicineNeurophysiology and Neural RepairHirokazu HiraiExt. 7930 hirai@gunma-u.ac.jpWe are studying the mechanism underlying memory, learning and motor control as well as brain disorders and aging in terms of molecular, cellular, network and behavioral aspects. Our challenge includes development of novel therapies effective for the brain disorders. To pursue these aims, we are developing cutting-edge techniques such as novel viral vectors, genome editing technology and disease model non-human primates. Our laboratory has sufficient experimental setup to perform world top-level research.【Keywords】Memory, Learning, Motor control, Regenerative medicine, Viral vector, Neurodegenerative disease, Marmoset, Non-human primate model, Aging, Stem cell therapy, Gene therapy, Patch clamp.Neurobiology and BehaviorTomoaki ShiraoExt. 8050tshirao@gunma-u.ac.jpTo understand the regulatory mechanisms of synapse morphology and function, we have studied the actin cytoskeleton in postsynaptic sites. For this research, primary cultured neurons, human iPS cells-derived neurons and knockout mice have been used with various experimental techniques including cell biology, biochemistry, molecular biology, neuronal cell culture, histochemistry, imaging and behavioral analysis. In addition, we have also studied about the e ects of radiation on the synapses. These studies will shed light on the mechanisms of brain function and development of new diagnostic and therapeutic methods for neurological and psychiatric disorders. 【Keywords】Synaptic morphology and function, Actin cytoskeleton, Imaging techniques, Human iPS cells-derived neurons, Radiation damage, High-throughputGenetic and Behavioral NeuroscienceYuchio YanagawaExt. 8040yuchio@gunma-u.ac.jpWe are studying the role of neurotransmitter GABA in brain functions such as emotion and the properties of GABAergic neurons through the generation and analyses of genetically engineered rodents such as conditional knockout mice and transgenic rats. We are also interested in the relationship between the deficits in GABAergic neurons and neuropsychiatric disorders. We have established model mice for schizophrenia or epilepsy and are characterizing them to elucidate the pathogenesis and/or pathophysiology of these disorders.【Keywords】neurotransmitter, GABA, knockout mice, transgenic rats, neuropsychiatric disorders, model mouseMolecular Pharmacology and OncologyMasahiko NishiyamaExt. 7960m.nishiyama@gunma-u.ac.jpOur department is home to research focused on (1) understanding biology of cancer to discover novel medical seeds (Basic Oncology), (2) understanding the mechanism of drug actions (Cancer Pharmacology), (3) developing new molecular diagnostics and cancer therapeutics including drug discovery and personalized medicine (Cancer Translational Research), based on the fundamental biology and OMICS research, which offers a broad range of basic and clinical research topics to educate professionals to become leaders in the elds of cancer pharmacology, translational research and R&D management　specialists.【Keywords】Cancer Pharmacology, Basic Oncology, Cancer Translational Research, Drug Action Mechanism, Genome-based Cancer Drug Discovery, Cancer BiomarkerBacteriologyHaruyoshi TomitaExt. 7990 tomitaha@gunma-u.ac.jpNosocomial infections caused by multi-drug resistant (MDR) bacteria have increased and become a worldwide social problem. Our research is focused on the major causative MDR bacteria including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), MDR Pseudomonas aeruginosa, and MDR Acinetobactor baumanni. The drug resistances and pathogenecities of MDR bacteria are examined by molecular biological methodology. The molecular mechanisms of bacterial genetic exchange system which is a signi cant factor for the spread of drug resistance and virulence genes are also studied.【Keywords】multi-drug resistant bacteria, VRE, MDRP, enterococcus, bacteriocin, conjugative plasmid, transposon－128－