群馬大学大学院医学系研究科 医科学専攻(博士課程) 平成30年度入学案内(英語版)

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RegionMajor FieldContact InformationMain contents of research and key wordsClinical MedicineRespiratory MedicineTakeshi HisadaExt. 8123hisadat@gunma-u.ac.jpClinical and basic researches for allergy and respiratory diseases are needed more than ever in our aging society. We try to investigate the pathogenesis of these diseases to make them clear. Our oncology unit is focusing on the basic and clinical research for lung cancer. Using genetically modi ed mice, research for refractory respiratory diseases such as asthma, COPD and lung brosis have been investigated.[Keywords]lung cancer, allergic respiratory disease, COPD, lung brosis, infectious lung diseaseGastroenterology and HepatologySatoru KakizakiExt. 8127kakizaki@gunma-u.ac.jpIn Gastroenterology Unit, we investigate pathophysiology and evaluate therapy of gastroesophageal reflux disease (GERD), gastrointestinal motility disorder including esophageal motility disorder, using high resolution manometry (HRM), intraluminal impedance & pH monitoring, gastric emptying assessed by 13C breath test, and frequency score for the symptom of GERD (FSSG). We started the new study entitled “association between inflammatory bowel disease and cellular stress response". In Hepatology Unit, main research themes are viral hepatitis, hepatocarcinogenesis, liver fibrosis and non-alcoholic steatohepatitis. We have investigated the pathogenesis of these disorders using animal models such as knockout mice, and analyzed clinical samples to establish new methods of the diagnosis and therapy.【Keywords】GERD, esophageal motility disorder, high resolution manometry, hepatocarcinogenesis, non-alcoholic steatohepatitis, knockout miceEndocrinology and MetabolismMasanobu YamadaExt. 8120myamada@gunma-u.ac.jpEndocrine metabolic system is an important biological signal transduction system, which transmits changes in a living body inside and outside to the target organ for eliciting appropriate biological responses. Collapse of this endocrine-metabolic system causes a variety of endocrine disorders, diabetes, and obesity, which reduces the patient's quality of life and leads to life-threatening cardiovascular disorders and malignant tumor. We are aiming to gain new insight into the pathogenesis of these disorders and develop new diagnostic methods and treatment by using genetically modi ed animal models, human gene analyses of surgical specimen and analyses of intracellular signaling system using molecular biology techniques.【Keywords】Lifestyle-related diseases, endocrine-metabolic disorders, diabetes mellitus, hypothalamus-pituitary-thyroid axis, adrenal gland, endocrine tumorNephrology and RheumatologyKeiji HiromuraExt. 8166hiromura@gunma-u.ac.jpWe are studying the molecular mechanisms of glomerular and tubulointerstitial injuries and renal tubular regeneration and trying to develop how to control renal injuries and regeneration. We are also examining the role of dendritic cells in renal diseases and autoimmune diseases. To investigate these research questions, we are using genetically modi ed animals and animal models of human diseases in vivo and several kinds of cultured cells in vitro. In addition, we are exploring and evaluating biomarkers for diagnosis or prognosis of renal and rheumatic diseases, using patients’ urine and tissue samples. 【Keywords】nephrology, rheumatology, autoimmune disease, regeneration medicine, biomarkersHematologyHiroshi HandaExt. 8166handahiroshi@gunma-u.ac.jpWe study genetic polymorphism and epigenome, comprehensive analysis of RNA, non-coding RNA, microRNA by Next Generation Sequencing (NGS), the carbohydrate metabolism to elucidate the mechanism of the development and the progression of hematologic malignancies. We also conduct study about genetic polymorphism relevant to opportunistic infection in HIV patients, genome wide analysis in congenital coagulation disorder in cooperation with other institutions including in foreign countries. Student will learn NGS, gene introduction into tumor cells and methods of clinical statistics to search a factor associated with disease development, taking advantage of hematologic disorder to be easy to obtain a specimen from human.【Keywords】hematologic malignancy, genome, epigenome, coagulation disorder, HIV, Next Generation Sequencer－130－