群馬大学大学院医学系研究科 医科学専攻(博士課程) 平成30年度入学案内(英語版)

136/162

RegionMajor FieldContact InformationMain contents of research and key wordsClinical MedicineNeurologyYoshio IkedaExt. 8060ikeday006@gunma-u.ac.jpTo develop early diagnostic tools and establish useful biomarkers for Alzheimer disease, we are investigating the Aβ-amyloid imaging (PIB-PET) and CSF biomarkers. To unravel a pathogenesis of the biggest intractable neurological disease, amyotrophic lateral sclerosis (ALS), we are investigating the autopsy tissues of ALS subjects. Microsatellite-repeat expansions of CAG, CTG, or GGCCTG repeat units are common genetic mutations of the hereditary neurological disorders such as spinocerebellar ataxia (SCA). We are trying to establish cell culture or animal models which are affected by these mutations. We hope to develop a novel disease-modifying therapy for SCA by analyzing these models.【Keywords】Alzheimer disease, dementia, amyotrophic lateral sclerosis (ALS), spinocerebellar ataxia (SCA), microsatellite-repeatCardiovascular SurgeryToru TakahashiExt. 8245torutaka@gunma-u.ac.jpAccording to an increase in aged population, the prevalence of arteriosclerotic diseases and heart failure are rapidly increasing, and part of such patients need surgical treatment. In cardiovascular surgery, organ ischemia occurs in almost all patients, and then the reduction of the ischemia-reperfusion injury is important to the surgical results. It is still controversial in the methods of myocardial protection and brain protection, and we study more e ective methods for organ protection.【Keywords】surgery, heart, brain, ischemia, reperfusion injury, organ protectionGeneral Thoracic SurgeryAkira MogiExt. 8224akmogi@gunma-u.ac.jpThe understanding of fundamental knowledge and concept of malignant diseases in thoracic surgical oncology, in particular, lung cancer, metastatic lung tumor, and thymic epithelial tumor is most important. The various factors related in each stage of carcinogenesis, proliferation, local invasion and also metastasis of tumor are reviewed with the latest knowledge. Furthermore, we make the students understands in the importance of the recent advances in the diagnosis and treatment to patients with thoracic malignant disease. After clarifying the clinical problems, the students will learn the basic experimental techniques necessary for development of new diagnostic method and therapy in surgical science of future.【Keywords】Surgical oncology, mechanism of proliferation, invasion and metastasis, driver gene, diagnosis and treatmentGastroenterological SurgeryHiroyuki Kuwano※Ext. 8220hkuwano@gunma-u.ac.jpIn Division of Gastroenterological Surgery, researches for whole digestive tract are included. A wide variety of research, which including mechanism of carcinogenesis, growth and invasion of tumor, metastasis of tumor, suppressive research of malignancy and gastrointestinal motility research with conscious dogs, it will read to new therapeutic treatment have been energetically performed. Moreover, several clinical researches including development of excellent diagnostic method and therapeutic method have been performed continuously for the future.【Keywords】gastrointestinal surgery, carcinogenesis, gastrointestinal motility, excellent diagnostic method, development of therapeutic methodBreast and Endocrine SurgeryTakaaki FujiiExt. 8224ftakaaki@gunma-u.ac.jpBreast Cancer is the highest incidence disease among female malignant neoplasm. We review diagnosis and treatment of breast cancer and endocrine disorders. Basic research includes 1) mechanism of therapy resistance in breast cancer, 2) tumor angiogenesis, 3) biomarker of sensitivity for breast cancer treatment, 4) an exhaustive analysis of breast cancer prognostic factors. In addition, clinical study includes 1) additional usefulness of FDG-PET in breast cancer, 2) Mechanism of lymph node metastasis, 3) analysis of navigation surgery for identi cation of parathyroid glands and sentinel lymph nodes. It is not necessary to focus on the speci c research subject, which you belong to. We held a research conference every week and discuss everything to solve the research problems with our professor.【Keywords】breast cancer, biomarkers, lymph node metastasis, TILs, microRNA, PET※Due to retire in March 2018 －131－