群馬大学大学院医学系研究科 医科学専攻(博士課程) 平成30年度入学案内(英語版)

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RegionMajor FieldContact InformationMain contents of research and key wordsCooperative Department and Joint DepartmentMolecular Tra cKen SatoExt. 8840 sato-ken@gunma-u.ac.jpMembrane trafficking plays essential roles not only in secretion and nutrient uptake but also in various physiological processes such as those involving the endocrine system, metabolic system, and nervous system in animals. In our laboratory, we study the molecular mechanisms and physiological functions of membrane trafficking in multicellular organisms by using the nematode Caenorhabditis elegans and mice as model systems. In addition, we study the molecular mechanisms underlying protein-misfolding diseases, in which abnormal membrane proteins accumulate in the endoplasmic reticulum (ER), in order to discover new targets for the treatment of such diseases.【Keywords】Membrane trafficking, Secretion, Metabolism, Development, Model animalMedical NeuroscienceAkiko Hayashi-TakagiExt. 8850 hayashitakagi@gunma-u.ac.jpThe deterioration of the synapses has attracted attention as the pathophysiology of neuropsychiatric disorders. Thus, we examine the relationship between the structural and functional property of synapse and behavioral manifestations by utilizing in vivo 2-photon imaging. Furthermore, we also utilize novel optogenetic tools, which can manipulate the plasticity of the synapse in order to alter neurocircuits by extension changing the behaviors. By these two strategies, we pursue the cellularmechanism of neuropsychiatric disorders to identify a novel therapeutic target for disorders.【Keywords】Neuropsychiatric disorders, synapse, 2-photon imaging, signal transduction, drug discoverySecretion BiologySeiji Torii(Associate Professor)Ext. 8859storii@gunma-u.ac.jpWith the decrease of neuroendocrine function, a variety of diseases increase, which include metabolic syndrome and neuronal disorders. To understand fundamental mechanisms on such human diseases, we investigate the biosynthesis and secretion of peptide hormones, and the regulation of cell survival and death, with use of molecular and cellular technical approaches. In a collaborative study with some engineering researchers, we are developing new compounds or uorescent probes for analyzing cancer, diabetes, and ischemia.【Keyword】Endocrine cells, Peptide hormones, Insulin, Molecular imaging, Reactive　oxygen species, FerroptosisMolecular Membrane BiologyMiyuki Sato(Associate Professor)Ext. 8843m-sato@gunma-u.ac.jpEukaryotic cells are composed of several membrane-bound organelles. The shape and composition of organelles are dynamically regulated during cell di erentiation and are also in uenced by various changes in the extracellular environment. We are interested in the regulation of organelle dynamics during animal development and use C. elegans as a model system. In particular, we explore the mechanisms and physiological roles of autophagy and endocytosis in fertilized eggs by using genetic and cell biological approaches.【Keywords】C. elegans, embryonic development, organelle, autophagy, endocytosisMolecular Endocrinology and MetabolismTetsuro IzumiExt. 8856 tizumi@gunma-u.ac.jpTo understand the physiopathology of multicellular organisms, it is important to know how diff erentiated cells communicate with each other to regulate their function as a whole body. We especially focus on the basic biology of pancreatic beta cells, adipocytes, and immune cells, because of their involvement in the pathogenesis of endocrine, metabolic, and allergic diseases such as diabetes, obesity and asthma. We approach these themes at multiple levels from molecules to whole body, and by using varying techniques of molecular biology, biochemistry, cell biology, and genetics.【Keywords】genetically modi ed mouse, regulated exocytosis, endocrine, metabolic, and allergic disease, live cell imaging, cell sorting－137－