群馬大学大学院医学系研究科 医科学専攻(博士課程) 平成30年度入学案内(英語版)

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RegionMajor FieldContact InformationMain contents of research and key wordsCooperative Department and Joint DepartmentDevelopmental Biology and MetabolismYoshio FujitaniExt. 8855 fujitani@gunma-u.ac.jpThe dysfunction of pancreatic beta cells, brown adipocytes, and enterocytes can cause diabetes and metabolic syndrome. Our goal is to elucidate the molecular mechanism involved in the maintenance of homeostasis of these higher-order function cells, which is the key to glucose metabolism. We aim to elucidate the mechanism of cellular homeostasis, from a variety of viewpoints, including developmental biology, zinc biology, autophagy, and cell polarity, by effectively utilizing genetically engineered mice. Furthermore, using our ndings from basic medical research, we aim to establish a groundbreaking treatment for diabetes and obesity.【Keywords】diabetes, glucose metabolism, developmental biology, pancreatic beta cells, genetically engineered mice, brown adipocytes, zinc biology, autophagyMetabolic SignalingTadahiro KitamuraExt. 8845 kitamura@gunma-u.ac.jpIn this laboratory, we are trying to elucidate the molecular mechanism by which metabolic syndrome occurs, using genetically manipulated animal models, such as knockout mice or transgenic mice. We hope that our research will contribute to the development of new strategies to treat or prevent diabetes and obesity.【Keywords】diabetes, obesity, metabolic syndrome, transcription factor, knockout mouse, insulin glucagonLaboratory of Epigenetics and MetabolismTakeshi InagakiExt. 8835inagaki@gunma-u.ac.jpEpigenetic regulation of gene expression is independent of genomic sequence and therefore can exibly respond to environmental factors. We are currently investigating various epigenetic mechanisms by which the environmental factors are linked to metabolic diseases. Main focus of our research is histone modification which regulates gene expression through changing chromatin structure and cofactor recruitment. Using techniques of transcriptomics, epigenetics, proteomics and animal models, we intend to elucidate the detail mechanisms of epigenetic regulations of energy metabolism and adipose cell development.【Keywords】Epigenome, metabolic diseases, energy metabolism, transcription, chromatin structureMolecular GeneticsTakayuki YamashitaExt. 8830 y-taka@gunma-u.ac.jpCells are constantly exposed to diverse genotoxic and proteotoxic stresses derived from environmental and intrinsic sources. Cellular responses to these stresses play essential roles in oncogenesis, degeneration and aging. Our research focuses on the molecular mechanisms underlying the cellular responses to DNA replication stress and heat shock and their pathological functions in cellular senescence and oncogenic transformation.【Keywords】DNA replication stresses, Heat shock response, Cellular senescence, Genomic instability, OncogenesisGenome SciencesIzuho HatadaExt. 8057hatada@gunma-u.ac.jpEpigenetics is the study of heritable codes other than genetic codes written in A,G, C, and T. Monozygotic twins have the same genetic information; however, they have di erent epigenetic information and phenotype. DNA methylation and histone modifcations (acetylation and methylation) serve as epigenetic code. Epigenetic status, namely, epignome, is thought to be in uenced by the environment, such as food, infection, and chemicals. This reprogramming of the epigenome by the environment could cause diseases such as cancer, and diabetes. We are going to clarify the role of epigenetic anomalies in diseases such as cancer, diabetes and obesity.【Keywords】epigenetics, epigenome, DNA methylation, microarray, genome-wide analysis－138－